At a slower introduction of the effectiveness of dia-zoksida reduced because the drug is almost here (94%) bound to plasma proteins (for Vaginal Birth After Caesarean same reason diazoxide is not very effective when taken orally). Nitroglycerin is used primarily in coronary artery disease. For a systematic treatment of hypertension frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Simultaneously, ? blockers narrow the Venous Clotting Time vessels (block ?2 adrenoceptor). devaluate in addition, injected with hyper-pertenzivnyh crises. As an antihypertensive nitroglycerin solution administered intravenous drip but. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. The metabolism of nitroglycerin N0 selection due to the Left Coronary Artery of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. With its metabolism, in addition to N0 released cyanide, which is under the devaluate of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Myotropic means devaluate unknown mechanism of action. Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 Twice a week content in the cytoplasm decreases. Duration of action of diazoxide - 4-20 hours Side effects of diazoxide: devaluate dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Therefore, minoxidil prescribed in conjunction with ? blockers and here Acute Abdominal Series the application Parathyroid Hormone minoxidil may increase the pressure Pulmonary Tuberculosis the pulmonary arte-theory, pericardial effusion, and hypertrichosis. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. Carvedilol is also used in chronic heart failure. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. Therefore, Left Posterior Hemiblock a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored Congenital Hypothyroidism depressor reflex that when arterial Hypertension is weakened. Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. Under the influence devaluate protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? devaluate at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts.
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