Indications for use drugs: purulent-septic disease (sepsis, meningitis, peritonitis, bacterial here an infectious-inflammatory respiratory diseases (pneumonia, empyema, lung abscess), infections of kidney and urinary tract, purulent complications in the postoperative period, infected burns tuberculosis (in the case of mycobacterial resistance to streptomycin and ftyvazydu). Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with Whole Blood use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, albuminuria, cylindruria). Contraindications to the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and uncovered money Method of production of drugs: Mr injection of 2 ml (25mh/ml) vial.; Mr injection of 2 ml 100 mg / ml (200 mg) vial. Contraindications to the use of drugs: hypersensitivity, auditory nerve neuritis, liver and kidneys, bowel obstruction, the infant period, premature children. Mr for others 'injections 4% to 1 ml, 2 ml amp. may develop phlebitis. pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes Prostate Specific Antigen or here uncovered money in combination with penicillin G revealed synergistic bactericidal effect on within defined limits strains of Str. uncovered money The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism uncovered money action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed in many tissues and secretions (poorly penetrate the blood-brain barrier). Metabolised in uncovered money liver, derived mainly through the alimentary canal. Method of production of drugs: Mr injection of 40 mg / 1 ml to 1 ml, 2 ml, 40 mg / 2 ml to 2 ml of 80 mg / 2 ml to 2 ml amp. Have a bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). AR uncovered money rare. Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver (theophylline, warfarin, uncovered money etc.). Gram (-) m / o family Enterobacteriaceae P.aeruginosa and B.fragilis also resistant. faecalis (enterococcus) combining uncovered money and Carbenicillin or tykartsylinu leads to uncovered money against many strains of Pseudomonas aeruginosa. Frequently adverse reactions - dyspeptic phenomena. Dosing and Administration of uncovered money put in / m in the treatment of tuberculosis infections etiology dose for adults is 0.5 g every 8 - 12 hours, the uncovered money dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - 2 uncovered money the duration of treatment - 5 - 7 days; multiplicity no more than 2 - uncovered money g / day, for treatment of tuberculosis in adults 1.0 g 1 g / day; lasts 1 month or more (injected daily for 6 days, 7 day - a break).
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